This study aimed to determine effect of discrimination perception on disability acceptance, mediating effects of family health and self-esteem, and serial multiple mediation effects of family health and self esteem in the relationship between discrimination perception and disability acceptance of acquired disability. The 1st Disability Life Panel Survey (DLPS) data were used for analysis. As study samples, 4,615 of this research were those who answered all variables. Frequency, reliability, regression analysis, and bootstrapping were performed using SPSS 26.0 and PROCESS Macro. Results of analyses revealed that discrimination perception showed a negative (-) effect on disability acceptance. In addition, mediating effects of family health and self-esteem between discrimination and disability acceptance and serial multiple mediating effects of family health and self-esteem were verified. These findings suggest that not only acquired disability itself, but also family are important to those with disability. Thus, related systems and programs should be developed with a longitudinal approach rather than a cross-sectional approach.